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Future research should focus on well-designed, long-term RCTs evaluating fluoxetines metabolic effects in non-depressed overweight and obese individuals, as most existing studies include participants with comorbid depression

A 2021 study on nalfurafine, a -opioid agonist metabolized by cytochrome P450 into an inactive form, showed significant improvement in pruritus scores without notable adverse effects at doses of 2.5 mg and 5 mg, regardless of daytime or nighttime itching (24)

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